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Authors Kohli M, Williams K, Yao JL, Dennis RA, Huang J, Reeder J, Ricke WA
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Journal Cancer Invest. Volume: 29 Issue: 1 Pages: 62-7
Publish Date 2011 Jan
PubMed ID 21166500
PMC ID 3136353

A variable repertoire of coagulation protein expression is observed in different cancers. We evaluated expression of thrombin in prostate tissue.Detection of thrombin was performed using quantitative real-time PCR in fresh tissue and in situ hybridization (ISH) in archival prostate tissue and by immunohistochemistry of prostate tissue microarrays.(Pro)thrombin mRNA expression was detected in cancer tissue and localized to prostatic epithelium and stroma by ISH. Thrombin protein was detected in stroma of benign and malignant epithelium (p <.05).Prostate tissue is a rich reservoir of thrombin. This may have potential for developing antithrombin-based cancer therapy.

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