|Authors||McLorie GA, McKenna PH, Greenberg M, Babyn P, Thorner P, Churchill BM, Weitzman S, Filler R, Khoury AE|
|Journal||J. Urol. Volume: 146 Issue: 2 ( Pt 2) Pages: 509-13|
|Publish Date||1991 Aug|
During the last 6 years a treatment protocol of radiographic staging along with percutaneous biopsy to establish a histological diagnosis has been used in 37 patients with Wilms tumor. Combination chemotherapy was given for 4 to 6 weeks before definitive surgical resection. In 9 patients tumor shrinkage was sufficient to permit preservation of a portion of the affected kidney(s). In stage V disease partial nephrectomy was accomplished in 5 patients. In 4 additional patients with unilateral disease downstaging also allowed partial nephrectomy. The radiological and histological changes that allowed this limited surgery are analyzed and compared.