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Welcome to the Urinary Biomarkers of Lower Urinary Tract Symptoms (LUTS) in Men Project Website

The project is funded through an NIH/NIDDK initiative as a new Planning Center for Interdisciplinary Research in Benign Urology (P20 DK097826-01)

Overview of Our Center

Lower urinary tract symptoms (LUTS) are a spectrum of urinary disorders involving:

  • Sensation of incomplete bladder emptying, increased urinary frequency and urgency (especially at night)
  • Weak or intermittent stream, straining, and painful urination

Who is at risk for LUTS?

  • Men and women, especially aging men and women
  • Individuals who are obese or have type 2 diabetes
  • Individuals who have had a spinal cord injury, neurodegenerative or autoimmune disease
  • Individuals who suffer from sleep-disordered breathing
  • Individuals with a history of chronic urinary tract or prostate infection

What causes LUTS?

  • Prostate enlargement
  • Urethral narrowing
  • Diminished sensation of bladder filling
  • Bladder muscle weakness
  • Loss of bladder control
  • Other factors not currently understood

The challenge of treating LUTS:
LUTS are caused by a set of very different anatomical and biochemical problems that require specialized therapeutic approaches. Current therapies do not take into account the different causes of LUTS.

Our Research Goals:

  • Develop research tools that reveal how urinary function is controlled and why it deteriorates in aging men
  • Identify LUTS biomarkers, using state of the art proteomic and metabolomics processes, to classify LUTS patients into subgroups based on the underlying cause of their symptoms

Interested in contributing?
At the University of Wisconsin-Madison Center for Interdisciplinary Research in Benign Urology, we welcome your:

  • Thoughts and ideas. Share them with our growing group of scientists and trainees by attending our research meetings.
  • Collaboration. We encourage new collaborations across the UW-Madison campus and beyond. You can participate in one of our existing studies or collaborate with us on our new initiatives.
  • Advocacy. Unfortunately, most men will suffer from urinary dysfunction at some point in their lives. Yet, urinary problems associated with prostate enlargement and other factors are sensitive and personal matters and are often not discussed. Please help us shed this stigma by starting and participating in the conversation! Also, contact your legislators and request that they support increased Federal commitment to bringing a cure to benign prostatic disease.

Questions or comments? Contact us.
Shana Peterson
peterson@urology.wisc.edu


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