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Urology, University of Wisconsin - Madison

O'Brien Urology Research Center Funded at UW

A National Institutes of Health (NIH) grant for more than $4 million was
recently awarded to the UW to fund a George M. O'Brien Urology Research
Center. Wade Bushman, MD, PhD, is the principal investigator of the
grant entitled "Mechanisms for Acquired Changes in Prostate Growth
Regulation."

The UW O'Brien Center, funded by the National Institute of Diabetes and
Digestive and Kidney Diseases and the National Cancer Institute, seeks
to attract new scientists to investigate the mechanisms of urologic
diseases and disorders, encourage multidisciplinary research focused on
the causes of urologic diseases, and generate developmental research
that will lead to new approaches to study urologic diseases. The grant's
unifying hypothesis is that aging and the environment produce acquired
changes in prostate growth control that predispose to neoplasia. The
grant involves collaboration among investigators from the Medical
School, School of Pharmacy and School of Veterinary Medicine; includes
initiatives to attract researchers with common interests; and funds two
to three developmental projects annually.

In addition to Bushman, key investigators include David Jarrard, MD,
associate professor of surgery; Hasan Mukhtar, PhD, professor of
dermatology; Terry Oberley, MD, PhD, professor of pathology and
laboratory medicine; Richard Peterson, PhD, professor of pharmacy; John
Svaren, PhD, assistant professor of comparative biosciences; and George
Wilding, MD, professor of medicine.

F. Michael Hoffman, PhD, professor of oncology and medical genetics, and
Douglas McNeel, PhD, assistant professor of medicine, received
competitive awards for developmental projects at the onset of the grant.
Funding will be available in future years for additional
developmental/pilot and feasibility projects. Junior investigators, as
well as established investigators with new research interests related to
prostate growth, are encouraged to consider this opportunity.

Anyone with research interests that complement those of the O'Brien
Center group is encouraged to contact Bushman or one of the other
investigators.

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