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O'Brien Urology Research Center Funded at UW

A National Institutes of Health (NIH) grant for more than $4 million was recently awarded to the UW to fund a George M. O’Brien Urology Research Center. Wade Bushman, MD, PhD, is the principal investigator of the grant entitled “Mechanisms for Acquired Changes in Prostate Growth Regulation.”

The UW O’Brien Center, funded by the National Institute of Diabetes and Digestive and Kidney Diseases and the National Cancer Institute, seeks to attract new scientists to investigate the mechanisms of urologic diseases and disorders, encourage multidisciplinary research focused on the causes of urologic diseases, and generate developmental research that will lead to new approaches to study urologic diseases. The grant’s unifying hypothesis is that aging and the environment produce acquired changes in prostate growth control that predispose to neoplasia. The grant involves collaboration among investigators from the Medical School, School of Pharmacy and School of Veterinary Medicine; includes initiatives to attract researchers with common interests; and funds two to three developmental projects annually.

In addition to Bushman, key investigators include David Jarrard, MD, associate professor of surgery; Hasan Mukhtar, PhD, professor of dermatology; Terry Oberley, MD, PhD, professor of pathology and laboratory medicine; Richard Peterson, PhD, professor of pharmacy; John Svaren, PhD, assistant professor of comparative biosciences; and George Wilding, MD, professor of medicine.

F. Michael Hoffman, PhD, professor of oncology and medical genetics, and Douglas McNeel, PhD, assistant professor of medicine, received competitive awards for developmental projects at the onset of the grant. Funding will be available in future years for additional developmental/pilot and feasibility projects. Junior investigators, as well as established investigators with new research interests related to prostate growth, are encouraged to consider this opportunity.

Anyone with research interests that complement those of the O’Brien Center group is encouraged to contact Bushman or one of the other investigators.


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